新闻分类
联系方式
地址:深圳市福田区福田街道金田路3037号金中环商务大厦2907
电话:027-50458986
手机:18627928100
E-MAIL:179172802@qq.com
网址:http://www.dxhgxs.com
新闻内容 当前位置:网站首页 >> 新闻中心 >> 行业资讯 >> 详细信息

RAD140英文介绍

发布者:RAD140-深圳市华莱生物科技有限公司  发布时间:2017-11-11  阅读:507次
RAD140英文介绍
 RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). IC50 value: 7 nM (Ki, fot androgen receptor) [1] Target: androgen receptor in vitro: RAD140 demonstrates excellent affinity for the androgen receptor (Ki = 7 nM) as well as good selectivity over other steroid hormone nuclear receptors, with the closest off target receptor being the progesterone receptor (IC50 = 750 nM). [1] RAD140 is a novel SARM with high affinity and specificity for AR, is orally available, and exhibits potent anabolic effects in rodents and nonhuman primates.[2] in vivo: The stability of RAD140 is high (t1/2 > 2 h) in incubations with rat, monkey, and human microsomes, and it also had good bioavailability in rats and monkeys. [1] RAD140 is also neuroprotective using the rat kainate lesion model. RAD140 is shown to exhibit peripheral tissue-specific androgen action that largely spared prostate, neural efficacy by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate.[2]

上一篇: rad140-2018年价格趋势
下一篇: rad140实验方法
Copyright © 2004-2015 
 深圳市华莱生物科技有限公司    All Rights Reserved 版本所有
24小时服务热线: 18627928100      公司邮箱:179172802@qq.com
公司地址:深圳市福田区福田街道金田路3037号金中环商务大厦2907  QQ:179172802 技术支持:华莱生物科技
rad140
 
 
收缩
  • QQ咨询

  • RAD140-深圳市华莱生物科技有限公司
  • RAD140-深圳市华莱生物科技有限公司
  • 电话咨询

  • 15629142025